The REACT study
The REACT study
The REACT study
The REACT study
The REACT study

Aims and Objectives

Aim

 

The primary aim of the REACT study is to assess the effectiveness and cost-effectiveness of a community-based physical activity intervention for reducing the progression of mobility-related functional limitations in older people who are at high risk of transition from independence to mobility-related disability.

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Primary objectives

  1. To adapt a previously successful exercise programme delivered in the USA (the LIFE intervention), for use in UK community settings.

  2. To conduct an internal pilot study to evaluate and optimise the feasibility and acceptability of the REACT intervention to older people and intervention providers. We will also evaluate the proposed trial methods across a diverse sample, spanning multiple ethnic groups and areas varying in levels of deprivation.

  3. To conduct a full-scale pragmatic multi-centre randomised controlled trial of the REACT intervention with data collection at baseline and 6, 12 and 24 months of follow up.

  4. To explore how intervention effectiveness varies with level of deprivation and ethnicity (i.e. to explore potential effects on health inequalities).

Secondary objectives

 

  1. To compare minutes of moderate intensity physical activity, as measured by accelerometer data, between intervention and control groups

  2. To compare sedentary time and breaks in sedentary time between intervention and control groups.

  3. To compare self-reported physical activity between intervention and control groups.

  4. To compare hand grip strength of the dominant hand between intervention and control groups.

  5. To compare performance on a brief test of cognitive function between intervention and control groups.

  6. To compare the rate of brain atrophy and performance on more detailed tests of cognitive function and gait analysis tests between intervention and control groups (fMRI imaging sub-study).

  7. To compare mental and social well-being, energy, sleep quality and pain between intervention and control groups.

  8. To compare health-related quality of life between intervention and control groups.

  9. To compare activities of daily living (ADL) scores between intervention and control groups.

  10. To conduct a full economic evaluation to estimate the incremental cost-effectiveness of the REACT intervention compared to control i.e. incremental cost per unit of health outcome.